Scientists are beginning to examine whether the psychedelic brew known as ayahuasca can help reduce suicide risk. Ayahuasca, a psychedelic concoction used for centuries by indigenous Amazon tribes, contains the powerful psychedelic drug dimethyltryptamine (DMT). “Suicide is one of the leading causes of death, accounting for nearly 1 million deaths each year,” said study author Richard Zeifman, a PhD student in Clinical Psychology at Ryerson University. The researchers conducted a secondary analysis on data from a randomized placebo-controlled trial, which was published in Psychological Medicine in 2019. The study provided preliminary evidence that the psychedelic brew had rapid antidepressant effects. “When administered within the appropriate context, and with proper preparation, the psychoactive brew ayahuasca may show promise as an intervention for suicidality,” Zeifman told PsyPost. In the study, 29 participants with treatment-resistant depression and no history of psychotic disorders were randomly assigned to undergo a single treatment session, in which they were given either ayahuasca or a placebo substance to drink. None of the participants had prior experience using psychedelics. “These findings help to extend past research on the potential therapeutic benefits associated with ayahuasca. Nonetheless, our findings are preliminary and suggest that there is an important need for additional research exploring the potential therapeutic benefits associated with ayahuasca.”
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